diff --git a/av1/common/av1_rtcd_defs.pl b/av1/common/av1_rtcd_defs.pl
index 0e33221..c4538df 100644
--- a/av1/common/av1_rtcd_defs.pl
+++ b/av1/common/av1_rtcd_defs.pl
@@ -182,7 +182,8 @@
 add_proto qw/void av1_highbd_dr_prediction_z1/, "uint16_t *dst, ptrdiff_t stride, int bw, int bh, const uint16_t *above, const uint16_t *left, int upsample_above, int dx, int dy, int bd";
 specialize qw/av1_highbd_dr_prediction_z1 avx2/;
 add_proto qw/void av1_highbd_dr_prediction_z2/, "uint16_t *dst, ptrdiff_t stride, int bw, int bh, const uint16_t *above, const uint16_t *left, int upsample_above, int upsample_left, int dx, int dy, int bd";
-specialize qw/av1_highbd_dr_prediction_z2 avx2/;
+# Disabled avx2 version due to Valgrind issue(https://bugs.chromium.org/p/aomedia/issues/detail?id=2441).
+# specialize qw/av1_highbd_dr_prediction_z2 avx2/;
 add_proto qw/void av1_highbd_dr_prediction_z3/, "uint16_t *dst, ptrdiff_t stride, int bw, int bh, const uint16_t *above, const uint16_t *left, int upsample_left, int dx, int dy, int bd";
 specialize qw/av1_highbd_dr_prediction_z3 avx2/;