diff --git a/tests/CMakeLists.txt b/tests/CMakeLists.txt
index b328048..099457d 100644
--- a/tests/CMakeLists.txt
+++ b/tests/CMakeLists.txt
@@ -116,6 +116,10 @@
     target_link_libraries(avify4mtest aviftest_helpers ${GTEST_BOTH_LIBRARIES})
     target_include_directories(avify4mtest PRIVATE ${GTEST_INCLUDE_DIRS})
     add_test(NAME avify4mtest COMMAND avify4mtest)
+
+    if(NOT libsharpyuv_FOUND)
+        message(STATUS "Some tests are skipped because libsharpyuv is unavailable.")
+    endif()
 else()
     message(STATUS "Most tests are disabled because AVIF_ENABLE_GTEST is OFF.")
 endif()
diff --git a/tests/gtest/avifrgbtoyuvtest.cc b/tests/gtest/avifrgbtoyuvtest.cc
index 81b5675..b9f8013 100644
--- a/tests/gtest/avifrgbtoyuvtest.cc
+++ b/tests/gtest/avifrgbtoyuvtest.cc
@@ -203,7 +203,13 @@
             ModifyImageChannel(&src_rgb, offsets.b, kBlueNoise);
           }
 
-          ASSERT_EQ(avifImageRGBToYUV(yuv.get(), &src_rgb), AVIF_RESULT_OK);
+          const avifResult result = avifImageRGBToYUV(yuv.get(), &src_rgb);
+          if (result == AVIF_RESULT_NOT_IMPLEMENTED &&
+              src_rgb.chromaDownsampling ==
+                  AVIF_CHROMA_DOWNSAMPLING_SHARP_YUV) {
+            GTEST_SKIP() << "libsharpyuv unavailable, skip test.";
+          }
+          ASSERT_EQ(result, AVIF_RESULT_OK);
           ASSERT_EQ(avifImageYUVToRGB(yuv.get(), &dst_rgb), AVIF_RESULT_OK);
           GetDiffSumAndSqDiffSum(src_rgb, dst_rgb, &diff_sum, &abs_diff_sum,
                                  &sq_diff_sum, &max_abs_diff);
@@ -290,7 +296,12 @@
         testutil::FillImageChannel(&src_rgb, offsets.a, rgb_max);
       }
 
-      ASSERT_EQ(avifImageRGBToYUV(yuv.get(), &src_rgb), AVIF_RESULT_OK);
+      const avifResult result = avifImageRGBToYUV(yuv.get(), &src_rgb);
+      if (result == AVIF_RESULT_NOT_IMPLEMENTED &&
+          src_rgb.chromaDownsampling == AVIF_CHROMA_DOWNSAMPLING_SHARP_YUV) {
+        GTEST_SKIP() << "libsharpyuv unavailable, skip test.";
+      }
+      ASSERT_EQ(result, AVIF_RESULT_OK);
       ASSERT_EQ(avifImageYUVToRGB(yuv.get(), &dst_rgb), AVIF_RESULT_OK);
       GetDiffSumAndSqDiffSum(src_rgb, dst_rgb, &diff_sum, &abs_diff_sum,
                              &sq_diff_sum, &max_abs_diff);